Best known for her portrayal of Annie, the rather promiscuous neighbor on the popular sitcom Caroline in the City, Amy Pietz received a 1998 Screen Actors Guild Award nomination for Best Actress in a Comedy. Other television credits include a regular role on The Webster Show and Muscle, as well as a recurring character on Ally McBeal. She has starred in the telefilms Call for Help and All Lines End in Murder, and guest starred in series such as ER, CSI, The Drew Carey Show and The Division.

Pietz's theater credits include originating the role of Martha Boswell in the musical The Boswell Sisters at The Old Globe Theater, Christmas In Naples, at the Williamstown Theater Festival, the musicals Fiorello and Company at Reprise LA, and A View from The Bridge and You Can't Take It with You at the Steppenwolf Theater. She also starred in In the Flesh at the Organic Theater, The Love of the Nightingale at the Next Theater, A Dead Man's Apartment at the Met Theater and Waiting for Lefty at the Artistic Home, and produced the musical Xanadu Live at the Gasco Center Theater. She performed in radio plays with L.A. Theater Works, including A View from the Bridge (in addition to the stage play), The South Paw, After the Fall, Voir Dire, Dinosaur Dreams, The Cherry Orchard, Middle of the Night and Fallsettos.

Film credits include Rudy, Jingle All the Way, Jell-Ohh Lady (which she also produced), Dysenchanted and The Whole Ten Yards. Pietz is a founding member of the Eclipse Theater Company in Chicago and a graduate of the former Goodman School of Drama, which awarded her an "Excellence in the Arts" award for her work in radio, television and theater.